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Antti Nieminen Biovian CEO

4 Areas where a CDMO can help your Viral Vector project.

...for gene therapy products,” BioNews, 3 February 2020. [Online]. Available: https://www.bionews.org.uk/page_147567. “FDA Continues Strong Support of Innovation in Development of Gene Therapy Products,” 28 January 2020. [Online]. Available: https://www.fda.gov/news-events/press-announcements/fda-continues-strong-support-innovation-development-gene-therapy-products. Cytiva,...
BLOG Viral Vectors and gene therapy basics summarized

Viral Vector and gene therapy basics summarized

...report: Glybera. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002145/WC500135476.pdf. [11] Zolgensma https://www.fda.gov/media/126109/download [12] Luxturna https://www.fda.gov/media/109906/download [13] https://www.prnewswire.com/news-releases/adeno-associated-virus-aav-vector-based-gene-therapy-market-expected-to-grow-at-a-significant-cagr-of-43-4-during-the-study-period-2019-30–301213850.html [14] https://www.ema.europa.eu/en/medicines/human/referrals/zynteglo [15] Liu J, Seol DW. Helper virus-free gutless adenovirus (HF-GLAd): a new platform for gene therapy. BMB...
Viral Vector production services at Biovian

Viral Vector Production

...Eur. 2.7.1), NAT (Ph. Eur. 2.6.21), or REA. Vector concentration: qPCR, ddPCR Extraneous agents: In vitro assays (Ph. Eur. 2.6.16) QC tests for control cells Identification: Morphology (Ph. Eur. 5.2.3),...

Beginner’s guide to the production of AAV vectors for gene therapy – Mentored by a CDMO

...gene therapies. https://www.fda.gov/news-events/press-announcements/statement-fda-commissioner-scott-gottlieb-md-and-peter-marks-md-phd-director-center-biologics [2] Rare Disease Information. https://rarediseases.org/for-patients-and-families/information-resources/rare-disease-information/ [3] FDA approves novel gene therapy to treat patients with a rare form of inherited vision loss. https://www.fda.gov/news-events/press-announcements/fda-approves-novel-gene-therapy-treat-patients-rare-form-inherited-vision-loss#:~:text=FDA%20News%20Release-,FDA%20approves%20novel%20gene%20therapy%20to%20treat%20patients%20with,form%20of%20inherited%20vision%20loss&text=The%20U.S.%20Food%20and%20Drug,that%20may%20result%20in%20blindness. [4] Gene Therapy for...
Adenovirus vector GMP manufacturing_blog

Adenovirus vector GMP manufacturing in adherent cell cultures and suspension cell cultures.

...adenovirus vector project, aiming for clinical trials.    References [1] Global Data  [2] China approves first gene therapy, Nat Biotechnol. 2004; 22(1): 3–4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097065/  [3] Zabdeno https://www.ema.europa.eu/en/medicines/human/EPAR/zabdeno  [4] AZD1222 vaccine met primary efficacy endpoint in preventing COVID-19 https://www.astrazeneca.com/media-centre/press-releases/2020/azd1222hlr.html ...
QC Services as Part of CDMO Programs

Quality Control Services

...quality agreements. Stability study capabilities (for Drug Substances, Drug Products and buffers): Controlled cabinets for stability studies – Storage conditions according to ICH guidelines -70°C / -20°C / +5°C /...
Biovian receives excellent NPS score

Biovian received a high Net Promoter Score, 72 in the 2020 client satisfaction survey

...[1] Net Promoter Score Definition. https://www.medallia.com/net-promoter-score/#:~:text=The%20Net%20Promoter%20Score%20is,customer’s%20loyalty%20to%20the%20brand. [2] What Do Companies with High Net Promoter Score Have in Common? https://www.retently.com/blog/companies-high-nps/ [3] What is Net Promoter Score®? Your introduction to NPS. https://www.hotjar.com/net-promoter-score/#:~:text=Net%20Promoter%20Score%20(NPS)%20is,to%20the%20story%20than%20that....
Microbial Production

Microbial Production

...subsequent Drug Product batches manufactured, including cell banks. Soluble and insoluble processes. Cell line capabilities: E.coli, P.pastoris and other. All clinical phases – Phase I to Phase III. https://youtu.be/wchrSrGU898 Track...