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BLOG Viral Vectors and gene therapy basics summarized

Viral Vector and gene therapy basics summarized

...report: Glybera. http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Public_assessment_report/human/002145/WC500135476.pdf. [11] Zolgensma https://www.fda.gov/media/126109/download [12] Luxturna https://www.fda.gov/media/109906/download [13] https://www.prnewswire.com/news-releases/adeno-associated-virus-aav-vector-based-gene-therapy-market-expected-to-grow-at-a-significant-cagr-of-43-4-during-the-study-period-2019-30–301213850.html [14] https://www.ema.europa.eu/en/medicines/human/referrals/zynteglo [15] Liu J, Seol DW. Helper virus-free gutless adenovirus (HF-GLAd): a new platform for gene therapy. BMB...

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Viral Vector production services at Biovian

Viral Vector Production

...pressured air-locks for material and personnel entry and exit. The airlocks are composed of two parts (D- and C-grade) and are controlled with inter-locks. HEPA filters are placed across the...

Beginner’s guide to the production of AAV vectors for gene therapy – Mentored by a CDMO

...Granted FDA Fast Track Designation for GT005, an Investigational Gene Therapy for Dry Age-Related Macular Degeneration.https://www.businesswire.com/news/home/20200921005923/en/Gyroscope-Therapeutics-Granted-FDA-Fast-Track-Designation-for-GT005-an-Investigational-Gene-Therapy-for-Dry-Age-Related-Macular-Degeneration%22 [10] Adeno-associated Virus Serotypes: Vector Toolkit for Human Gene Therapy. https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(06)00204-8?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1525001606002048%3Fshowall%3Dtrue [11] In vivo...

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Adenovirus vector GMP manufacturing_blog

Adenovirus vector GMP manufacturing in adherent cell cultures and suspension cell cultures.

...adenovirus vector project, aiming for clinical trials.    References [1] Global Data  [2] China approves first gene therapy, Nat Biotechnol. 2004; 22(1): 3–4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7097065/  [3] Zabdeno https://www.ema.europa.eu/en/medicines/human/EPAR/zabdeno  [4] AZD1222 vaccine met primary efficacy endpoint in preventing COVID-19 https://www.astrazeneca.com/media-centre/press-releases/2020/azd1222hlr.html ...
Antti Nieminen Biovian CEO

4 Areas where a CDMO can help your Viral Vector project.

...for gene therapy products,” BioNews, 3 February 2020. [Online]. Available: https://www.bionews.org.uk/page_147567. “FDA Continues Strong Support of Innovation in Development of Gene Therapy Products,” 28 January 2020. [Online]. Available: https://www.fda.gov/news-events/press-announcements/fda-continues-strong-support-innovation-development-gene-therapy-products. Cytiva,...